Engineered nanoparticles as precise drug delivery systems
نویسندگان
چکیده
منابع مشابه
Nanoparticles as drug delivery systems.
Controlled drug delivery systems (DDS) have several advantages compared to the traditional forms of drugs. A drug is transported to the place of action, hence, its influence on vital tissues and undesirable side effects can be minimized. Accumulation of therapeutic compounds in the target site increases and, consequently, the required doses of drugs are lower. This modern form of therapy is esp...
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A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such mater...
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Albumin, a versatile protein carrier for drug delivery, has been shown to be nontoxic, non-immunogenic, biocompatible and biodegradable. Therefore, it is ideal material to fabricate nanoparticles for drug delivery. Albumin nanoparticles have gained considerable attention owing to their high binding capacity of various drugs and being well tolerated without any serious side-effects. The current ...
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Objective: The objective of this study was to examine and characterize topical eye drops with indomethacin-loaded poly(vinyl acetate) nanoparticles (IMC-p(VAc)-NPs). Methods: IMC-p(VAc)-NPs were obtained by emulsifier-free radical homopolymerization of the monomers in the presence of indomethacin in water and in an aqueous solution of Carbopol®. Thus obtained indomethacin nanocarriers were incl...
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Micelles are excellent devices to be used as controlled drug delivery systems since they exhibit the ability to protect the drug or encapsulated substance from the routes of degradation until they reach the site of action: moreover, they can pass through biological barriers and reach intracellular compartments. In addition, when a drug is administered and released from the dosage form, the kine...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2006
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.20796